When German medical student Marc is ejected into the tumultuous blaze of Cali, Colombia, everything in this place smells like adventure and beautiful women to him, promising a perfect antidote to the menacing routine of the small-town surgeries back home. But soon, the archaic injuries he has to deal with as an intern at the Cali hospital will lure him towards Siloé, a picturesque neighbourhood of teenage hired assassins.

Marc's urge to understand the reality of a world so contrary to his own will make him disobey fear, waging a hazardous juggle with all kinds of debauchery, real-life assassins and his new status of being the neighbourhood's "Dr. Alemán".